Poster Presentation Asia Pacific Neuroendocrine Tumour Society 2018

Neuroendocrine neoplasms in the paediatric adolescent and young adult population in New Zealand and Queensland Australia (#123)

David Wyld 1 2 , Julie Moore 3 , Kate Parker 4 , Sharon Pattison 5 , Ruellyn Cockcroft 6 , Nancy Tran 3 , Ben Lawrence 4 6
  1. Department of Medical Oncology, Royal Brisbane Hospital, Herston, QLD, Australia
  2. School of Medicine, University of Queensland, Brisbane, Queensland, Australia
  3. Queensland Cancer Control Analysis Team, Princess Alexandra Hospital, Brisbane, Queensland, Australia
  4. Faculty of Medicine and Health Science, University of Auckland, Auckland, New Zealand
  5. Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
  6. Auckland District Health Board, Auckland, New Zealand

BACKGROUND: Multiple studies have shown the incidence of Neuroendocrine neoplasms (NENs) to be increasing worldwide. However, information in the paediatric, adolescent and young adult (PAYA) patient group is sparse globally. This retrospective population-based analysis describes the incidence and mortality of NENs in the PAYA population in two regions with similar population sizes - New Zealand and Queensland, Australia.

METHODS: Data regarding individuals <30 years diagnosed with NENs between 2008 and 2012 was obtained from the Queensland Oncology Repository and the New Zealand based NETwork! Register. Findings include overall and site-specific incidence, histopathologic subtype, and cause specific mortality.

RESULTS: 170 NENs were diagnosed in Qld and 123 in NZ between 2008 and 2012. 65% in NZ and 68% in Qld were females. The majority (>84%) in both populations occurred in patients 15 years of age and above. 79% of all NENs in Qld and 68% in NZ were in the appendix. 3 (1.7%) of the Qld and 9 (7.3%) of the NZ PAYA cohort had died of NEN.

In the subgroup <15 years 27 NENs were identified in Qld and 16 in NZ. The majority (>87%) occurred in the age group of 10 years and above in both cohorts. 25 Qld and 8 NZ cases were located in the appendix. 2 deaths were identified in the NZ cohort and no death occurred in Qld.

CONCLUSION: This study represents a comparison of two regions with similar population sizes and shows that the presentation of NENs in these two populations were found to be similar, with the majority of NENs in the PAYA population occurring in the appendix. Further work is required to understand subtle differences between the two data sets, which will provide important context to understanding other world comparisons of NEN epidemiology.